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  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
  • タイタンテクノロジーズ株式会社
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Particle Characterization

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NanoBrook_Particle Size Analyzer

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NanoBrook 173Plus / 90Plus

Nanoparticle Size Analyzer

 

 

NanoBrook 90Plus is a laboratory system for the determination of particle size in diluted suspensions using dynamic light scattering. Signals from two angles 173, 90 or 15 degrees are accessible. The 90Plus covers size range from about 1 nm to above 5 µm, depending on the physical properties of the sample material. A PC computer is integrated into the system.

 


 

Features

• Particle sizing from 1 < nm to 6 μm

• Multimodal and unimodal size distribution software

• Two scattering angles

• 35 mW laser with high sensitivity detector

• Upgradeable for zeta potential measurements

• 21CFR Part 11 option

• Molecular weight feature

• Accommodates wide concentration

• range for easy sample preparation

 

Typical Applications

• Proteins/complexes/DNA

• Polymer latexes

• Pharmaceutical preparations

• Oil/water and water/oil emulsions

• Paints and pigments

• Ink and toners

• Cosmetic formulations

 

Fast and sophisticated. Flexible and reliable. These are important attributes of an instrument that satisfies the needs of an ever widening community. If you have polymers or proteins, nanodots or new adhesives, latexes or liposomes, cosmetics or colloids, the Brookhaven Instruments 90Plus Nanoparticle Size Analyzer is the preferred tool to characterize your particles.

The 90Plus performs fast, routine submicron particle size measurements on a wide variety of samples and concentrations. It is an ideal instrument for measuring colloids, latexes, micelles, microemulsions, proteins, and other nanoparticles. Based on the principles of dynamic light scattering, most measurements only take a minute or two.

Simply put, the 90Plus puts the power of a highly sophisticated and easy to use instrument into your hands.

Imperfect Samples? The Brookhaven 90Plus provides simple to use but powerful tools to extract the most information from your sample. Brookhaven’s unique dust filter algorithm can remove the influence of a contaminating fraction of large particles (dust). Such particles can ruin a light scattering measurement; with the 90Plus it is often possible to rescue the measurement and obtain reliable data.

The flexible and intuitive Brookhaven software allows you to quickly, simply, and interactively test the effects of changing parameters and evaluation methods. It is straightforward for the novice to obtain key data quickly and versatile enough for advanced users to design complex measurements and customize output.

 

Friendly Application Software

Easy-to-use software allows rapid instrument setup and user training. Sophisticated statistical analysis of multiple run measurements is updated and displayed continually during the experiment allowing the user to determine the best measurement duration. Data from all or any selection of runs can be combined to give a single result. Data can be

presented in a variety of formats according to the user's needs. Among the 90Plus features are simple "Copy to Clipboard" and "Copy for Spreadsheet" buttons on each screen to facilitate moving graphs and tables to other applications for presentation and analysis.

 

Reproducibility

One important benefit for users is the reproducibility from sample-to-sample, operator-to-operator, and instrument-to-instrument. The optical design and quality control at Brookhaven ensures that every instrument performs the same. By automating much of the testing procedure and data analysis, effects due to different operators are dramatically reduced. Figure 1 shows the results from multiple runs on a test sample. Notice the standard error of the Effective (or Average) Diameter is much less than 1% of the mean of 10 repeated runs.

This excellent repeatability is typical of the 90Plus and necessary for routine QC analysis to ensure product quality time-after-time.

 

Applications

Many processes and products involve dispersions where optimal results depend on particle size. The technology to produce these dispersions, to ensure that they perform according to specifications, and to solve problems which may arise in production or use requires knowledge of the particle size. The 90Plus can handle many types of submicron samples. Quick routine measurements ensure that effects of process changes are rapidly measured and enable optimal process development. QC of incoming materials where particle size is important is another vital application for these instruments. Whether deciding to accept shipment or send product, rapid measurement means timely, accurate decisions. In addition, R&D efforts where particle size is a key parameter will benefit from the 90Plus. Applications include waste water treatment and stability of pigments, latexes, ceramics, and other colloidal dispersions.



 

Data Analysis and Presentation

 

The 90Plus offers three choices. For routine determinations, an average diameter (Eff. Dia.) and a distribution width (Polydispersity) are sufficient and valuable for QC analysis. The second choice is to show a lognormal distribution using these values, allowing the user to visualize the size distribution and to display cumulative and differential results at 5% intervals. The third choice, suitable for more complicated, multimodal size distributions is the use of advanced algorithms to obtain the particle size distribution. Here, a numerical algorithm, including Mie theory, is used. Results of this analysis for a mixture of latex particles are shown in Figure 2.

 

Advanced Features:

 

Integrated Statistical Process Control (SPC)

Built-in SPC charts ease the recording, tracking, and statistical analysis of process changes.

Temperature Series Studies (protein melting)

Evaluating the evolution of particle behavior with temperature is another feature of the 90Plus. One example is the change in micelle size with temperature. Another is the effect of temperature on protein melting or denaturation.

Zeta Potential Option

Besides particle size, zeta potential is the next most common parameter needed to understand colloidal behavior. Zeta potential is a measure of surface charge on a particle and is readily measured with the BI-Zeta option.

 

Zeta potential determination in solvents, oils, high salt concentrations, or very near the isoelectric point require a very sensitive detection technique. In these cases, add the BI-PALS option to the BI-Zeta. Phase Analysis Light Scattering (PALS) is up to 1,000 times more sensitive than traditional light scattering techniques.

 


 

 

 


 

 

 

 

 

 

 

 

Titan Technologies, K.K.

8-5-7-301 Minami-Senju, Arakawa-Ku, Tokyo 116-0003 Japan